Cyclooxygenase-2 Induction in Congestive Heart Failure
نویسندگان
چکیده
منابع مشابه
Cyclooxygenase-2 induction in congestive heart failure: friend or foe?
Cyclooxygenase-2, like the other member of the COX family, COX-1, is a bifunctional enzyme that catalyzes the conversion of arachidonic acid to PGG2 via COX activity and PGG2 to PGH2 via peroxidase activity. PGH2 is the precursor for PGs, prostacyclin, and TXA2. Hence, COX-2 occupies a central position in the biosynthesis of proinflammatory PGE2 and vasoactive prostacyclin and TXA2. COX-2 share...
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During a period of four years between June, IS, 1988 to June, IS, 1992 one hundred and fourteen patients with congestive heart failure (CHF) were admitted to the pediatric department of Taleghani General Hospital. During the above period, 192 patients with heart disease were hospitalized at this department and CHF was the cause of admission in 59.4% of them. Congenital heart disease (CHO) w...
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BACKGROUND Chronic heart failure is associated with induction of secondary inflammatory mediators, including prostanoids. The latter exert diverse functional and morphological effects on cardiac myocytes. Induction of cyclooxygenase (COX), the enzyme responsible for generating prostanoids, requires activation of nuclear factor-kappaB (NF-kappaB). The aim of the present study was to determine th...
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The heart is composed of two independent pumping systems, one on the left side and one on the right. The right chamber, or right atrium, of the heart relaxes and expands to fill with blood that has returned from the body. (This relaxed action causes diastolic pressure, recorded as the second and lower number when measuring blood pressure). The used blood is poor in oxygen and rich in carbon dio...
متن کاملCongestive heart failure.
Patients with acute decompensated heart failure are usually critically ill and require immediate treatment. However, most are not volume overloaded. Emergency department (ED) management is based on rapid initiation of noninvasive positive-pressure ventilation and aggressive titration of nitrates. Afterload reduction with an angiotensin-converting enzyme inhibitor can be considered. A diuretic s...
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ژورنال
عنوان ژورنال: Circulation
سال: 1998
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.98.2.95